Quantum dots glowing with visible light
Photo: Tayfun Ruzgar / Shutterstock
As we all know, antibiotics revolutionised medicine in the twentieth-century, allowing doctors to treat and prevent a whole range of nasty and potentially deadly bacterial infections.
However, as many of us also know, laziness and stupidity on the part of healthcare professionals, farmers and consumers, resulted in their misuse and overuse. Ultimately, prescribing and popping antibiotics as if they were medicinal Smarties, allowed bacteria to develop increasingly effective resistance; to become, in tabloid parlance, superbugs.
Antimicrobial resistance is now such a serious concern that England's chief medical officer, Prof. Dame Sally Davies, has taken to the airwaves to warn that modern medicine as currently practised is under threat and that many thousands of lives are already being lost due to drug-resistant infections.*
Indeed, somewhat hysterically, Davies refers to the possibility of a post-antibiotic apocalypse and demands that governments around the world take immediate action to prevent this. Otherwise, no more organ transplants, hip replacements, or caesarian sections. Cancer treatments would also become far riskier in the future - won't somebody please think of the children?
Thankfully, there is some good news to report; science might be able to meet the challenge of the superbugs not just with newly developed antibiotics, but with nanotechnology in the form of so-called quantum dots, or artificial atoms ...
However, as many of us also know, laziness and stupidity on the part of healthcare professionals, farmers and consumers, resulted in their misuse and overuse. Ultimately, prescribing and popping antibiotics as if they were medicinal Smarties, allowed bacteria to develop increasingly effective resistance; to become, in tabloid parlance, superbugs.
Antimicrobial resistance is now such a serious concern that England's chief medical officer, Prof. Dame Sally Davies, has taken to the airwaves to warn that modern medicine as currently practised is under threat and that many thousands of lives are already being lost due to drug-resistant infections.*
Indeed, somewhat hysterically, Davies refers to the possibility of a post-antibiotic apocalypse and demands that governments around the world take immediate action to prevent this. Otherwise, no more organ transplants, hip replacements, or caesarian sections. Cancer treatments would also become far riskier in the future - won't somebody please think of the children?
Thankfully, there is some good news to report; science might be able to meet the challenge of the superbugs not just with newly developed antibiotics, but with nanotechnology in the form of so-called quantum dots, or artificial atoms ...
Thanks to these strange, nano-sized crystals - invisible to the human eye - we have a significantly more potent weapon against drug-resistant microbes. In fact, QDs can supercharge traditional antibiotics making them up to a thousand times more effective.
Reacting as they do to certain frequencies of light, QDs can be photo-stimulated in such a manner as to disrupt vital chemical reactions that microbes - including superbug strains of E. coli and MRSA - require for their own well-being. It also appears that the dots can produce a compound known as a superoxide, which is readily absorbed by bacterial cells, further fucking-up their ability to produce energy and to develop.
It was discovered that QDs best carry out their murderous work when subject to green light. Unfortunately, green light can only penetrate a few millimetres beneath the surface of the human body, which means that QD-enhanced antibiotics can at present only treat skin infections or open wounds. The idea is that, eventually, hard-working biophysicists will work out how to trigger them with infra-red light.
Still, it's good to know that, thanks to quantum mechanics, there's hope that we won't all die off in the bacterial apocalypse imagined by Dame Sally and certain doom-mongering members of the World Health Organization.
Reacting as they do to certain frequencies of light, QDs can be photo-stimulated in such a manner as to disrupt vital chemical reactions that microbes - including superbug strains of E. coli and MRSA - require for their own well-being. It also appears that the dots can produce a compound known as a superoxide, which is readily absorbed by bacterial cells, further fucking-up their ability to produce energy and to develop.
It was discovered that QDs best carry out their murderous work when subject to green light. Unfortunately, green light can only penetrate a few millimetres beneath the surface of the human body, which means that QD-enhanced antibiotics can at present only treat skin infections or open wounds. The idea is that, eventually, hard-working biophysicists will work out how to trigger them with infra-red light.
Still, it's good to know that, thanks to quantum mechanics, there's hope that we won't all die off in the bacterial apocalypse imagined by Dame Sally and certain doom-mongering members of the World Health Organization.
As for those with concerns about using nanotechnology to fight disease, well they may continue to drink their own urine, perform caffeine enemas, or dabble with dragon's blood as is their wont ...
*Presently, the number of lives lost each year to drug-resistant infections is estimated to be 700,000. Failure to address the issue, however, is likely to see this figure increase globally to 10,000,000 by 2050.
*Presently, the number of lives lost each year to drug-resistant infections is estimated to be 700,000. Failure to address the issue, however, is likely to see this figure increase globally to 10,000,000 by 2050.
